早期生命阶段的热弹性是由气候相关的监管变化决定的
Joaquin C B Nunez1, Sumaetee Tangwancharoen1, Kylie M Finnegan1
1Dept. of Biology, University of Vermont, Burlington, VT 05405.
概括
这项研究揭示了影响果胚胎耐热性的遗传因素. 在自然选择下,特定的基因变异增强了在气候变化中生存的可能性.
科学领域:
- 进化生物学 进化生物学
- 发展遗传学 发展遗传学
- 环境生理学环境生理学
背景情况:
- 发育生理学的生态背景是研究不足的.
- 在Drosophila melanogaster中,热选择主要影响早期胚胎.
- 之前的工作确定了果胚胎中的热选择目标.
研究的目的:
- 在一个新热带Drosophila melanogaster系中绘制增强胚胎耐热性基因组基础.
- 为了确定特定的遗传位置和变异,负责热适应.
- 了解自然选择对发育基因的作用.
主要方法:
- 使用了先进的内进和整基因组组复序.
- 在六个复制的内向变化中,应用了16代热选择.
- 使用了全球人口比较和Drosophila遗传参考小组.
主要成果:
- 染色体2R和X上的两个位点被确定为热选择的目标.
- 在SP70和SOG基因的调节区域中,两个单核酸多态 (SNPs) 显示出临床和季节性模式.
- 这些位点的热带基因被证实会增加胚胎的耐热性,并以表皮性相互作用.
结论:
- 在SP70和SOG基因的发育调节变异是自然选择的结果.
- 在这些调节区域内基因表达的等位基因变异与耐热性相关.
- 这项研究表明,在Drosophila melanogaster.热耐受性方面,基因型与表型之间存在明显的联系.
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