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口腔癌中微RNA的表达分析,诊断和预后准确性:用元分析进行概述

Aishwarya Sukumaran Nair¹, Nanditha Sujir¹, Divyam Sen¹

¹Department of Oral Medicine and Radiology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.

International dental journal

|January 8, 2026

概括

微RNAs (miRNAs) 与口腔癌预后和诊断准确性有显著的关联. 升级的miRNAs表明生存率较差,而诊断测试显示中等至高的性能,需要标准化的临床使用方法.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物研究生物标志物研究

背景情况:

口腔状细胞癌 (OSCC) 构成了全球卫生挑战,原因是诊断迟到,预后工具有限.
在OSCC中,微RNA (miRNA) 被研究为早期检测和结果预测的潜在生物标志物.
研究方法的变化阻碍了miRNA生物标志物的临床翻译.

研究的目的:

综合关于口腔癌中miRNAs诊断准确性的证据.
为了评估miRNAs在口腔癌的预后意义.
分析口腔癌中miRNAs的差异表达.

主要方法:

对系统性审查和原始研究进行了元分析.
使用miRNA表达和生存的危险比率 (HRs) 评估预后意义.
用12项研究的曲线下面积 (AUC) 值来评估诊断准确性.
从11个条目中使用标准化平均差异 (SMD) 分析差异表达.

主要成果:

上调的miRNA表达显着与口腔癌中低生存率的风险增加2倍以上有关 (HR=2.31).
基于miRNA的测试显示了中等至高的诊断准确性 (AUC=0.787),非侵入性样本 (血清,唾液) 的高可变性.
瘤性miRNAs被上调 (SMD=+0.29) 和瘤抑制剂被下调 (SMD=-0.52),在整体分析中被掩盖.

结论:

不调节的miRNA表达与口腔癌的预后较差和诊断准确度中等至高有关.
一致的表达模式突出了miRNAs作为致癌或瘤抑制的作用.
方法的标准化和前性验证对于miRNA生物标志物的临床整合至关重要.

关键词:

诊断生物标志物诊断生物标志物进行元分析分析.口腔癌是一种口腔癌.预测生物标志物预测生物标志物系统性审查系统性审查微RNA (miRNA) 是一种微型RNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...