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血清粉样蛋白A作为PFAPA综合征攻击预测因素

Halil Kazanasmaz¹, Fırat Gündoğmuş¹, Ender Can Eroğlu¹

¹Karadeniz Technical University Faculty of Medicine, Department of Pediatric Rheumatology, Trabzon, Turkey.

Medicina clinica

|January 8, 2026

概括

血清粉样蛋白A (SAA) 是诊断周期性发烧,口腔口炎,喉炎和腺炎 (PFAPA) 综合征发作的高度准确的标志物. 与C-反应蛋白和红细胞沉积率相比,SAA显示出更高的灵敏度和特异性.

科学领域:

儿科儿科儿科
免疫学免疫学免疫学
临床诊断临床诊断临床诊断

背景情况:

周期性发烧,口腔炎,喉炎和腺炎 (PFAPA) 综合征是儿童常见的自身炎症性疾病.
准确及时诊断PFAPA对于适当的管理和将其与其他发烧性疾病区分开来至关重要.

研究的目的:

为了评估血清粉样蛋白A (SAA) 水平在PFAPA攻击期间的诊断效用.
为了比较SAA的诊断性能与其他炎症标记物,如C反应蛋白 (CRP) 和红细胞沉积率 (ESR).

主要方法:

对51名患有PFAPA和51名对照儿童的医疗记录进行了回顾性分析.
测量血清SAA,CRP,ESR和中性粒细胞与淋巴细胞比率 (NLR) 的水平.

主要成果:

与对照组相比,PFAPA患者的中位数SAA水平显著升高 (p<0.05).
接收器操作特征 (ROC) 分析显示,SAA在≥12.43mg/L时实现了100%的灵敏度和96.1%的特异性.
与CRP和ESR相比,SAA显示出更高的诊断准确性,比CRP的特异性更高,比ESR的特异性更高.

结论:

血清粉样蛋白A (SAA) 是PFAPA攻击的高度敏感和特定的生物标志物.
SAA比CRP和ESR具有更高的诊断准确性,使其成为PFAPA差异诊断的宝贵工具.

关键词:

氨基胺 A 血清在C-反应性蛋白质中.红细胞沉速度的速度中性粒细胞与淋巴细胞的比率.这就是PFAPA综合征.儿科风湿病学儿科风湿病学蛋白质C反应性蛋白质中性粒细胞/淋巴细胞的关系儿科的风湿病学.血清中的粉样蛋白A.综合症 PFAPAPA 综合症球状沉积速度的速度

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