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Updated: Jan 13, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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作为具有抗癌潜力的双COX-2/EGFR抑制剂的皮拉衍生物:对二胺醇类型的优化

Kawther O Farag1, Mai S Nour1, Mai M Abdelhafez2

  • 1Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), 6th of October City, Giza, Egypt.

Bioorganic chemistry
|January 8, 2026
PubMed
概括

针对COX-2和EGFR的新型药物化合物显示出治疗多种质母细胞瘤 (GBM) 的前景. 化合物10a表现出强大的双抑制和显著的GBM细胞毒性,特别是针对SNB-75细胞系.

关键词:
止痛药是一种止痛药.这是一种抗癌药物.在COX-2中,COX-2是最常见的.欧洲农业基金会 (EGFR) 是一个基金.质母细胞瘤 (glioblastoma) 是一个皮拉 (Pyrazole) 是一种可怕的药物.

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