维生素D补充剂和主要抑郁症的发生率 - 一个随机临床试验
Noora-Maria Ahl1, Sari Hantunen2, Tomi-Pekka Tuomainen2
1University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland.
Clinical nutrition (Edinburgh, Scotland)
|January 8, 2026
概括
长期服用维生素D3补充剂并没有防止5年以上的维生素D充足的成年人患重度抑郁症 (MDD). 随访时间较长表明可能有延迟的益处,因此需要对维生素D进行进一步的研究.
科学领域:
- 营养精神病学 营养精神病学
- 老年医学 老年医学
- 临床试验 临床试验
背景情况:
- 重度抑郁症 (MDD) 是一个公共卫生问题,主要预防策略有限.
- 维生素D在抑郁症治疗中的作用是公认的,但其在初级预防中的有效性仍然不清楚.
- 这项研究调查了长期维生素D3补充剂对MDD发病率的研究.
研究的目的:
- 为了确定长期的维生素D3补充是否会降低主要抑郁症 (MDD) 的发生率.
- 与安慰剂相比,评估不同维生素D3剂量 (1600 IU/天和3200 IU/天) 的影响.
- 探索维生素D3补充对MDD发病率的潜在延迟影响.
主要方法:
- 一个为期5年的随机,安慰剂控制的临床试验 (NCT01463813) 涉及2434名参与者.
- 参与者每天接受维生素D3 (1600 IU或3200 IU) 或安慰剂.
- 主要终点:补充剂期间发生的MDD诊断;次要终点:延长后续期间的MDD.
主要成果:
- 在所有组中,在5年补充期内,MDD发病率没有显著降低.
- 在维生素D3组中,在延长的随访期间 (平均7.8年) 观察到MDD事件的边界显著减少.
- 维生素D3补充剂增加了血清25-基维生素D度,特别是在3200 IU/天剂量时.
结论:
- 维生素D3补充剂在5年以上的维生素D充足的老年人中没有预防MDD.
- 维生素D3补充剂对MDD可能存在潜在的延迟保护作用.
- 需要进一步的研究来澄清维生素D3对情绪障碍的长期影响.
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