开发和验证多类固体相提取和液体色谱双重质谱法,用于水中新出现的污染物
Madara Weerasooriyagedara1, Jordan M Partington1, Wejdan Alghamdi2
1Australian Laboratory for Emerging Contaminants, School of Chemistry, University of Melbourne, Victoria, 3010, Australia.
Journal of chromatography. A
|January 8, 2026
概括
一种新的液体染色学-并联质谱法 (LC-MS/MS) 方法量化了水中的39种新出现的污染物. 这种强大的技术为环境监测和风险评估提供了超微量敏感度.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
背景情况:
- 新兴污染物 (ECs) 对水质和生态系统构成风险.
- 监测各种EC需要敏感和选择性的分析方法.
研究的目的:
- 开发和验证一个强大的,敏感的LC-MS/MS方法,用于同时量化39个多类EC.
- 评估该方法在各种水表中的适用性,并评估其环境可持续性.
主要方法:
- 优化LC-MS/MS参数 (过渡,源条件,移动阶段等). ) 的情况.
- 固相提取 (SPE) 的优化,以改善回收和减少矩阵效应.
- 验证该方法的线性,检测极限,恢复和精度.
主要成果:
- 达到超微量检测极限 (0.01 fg在列上,0.01-1.32 ng/L方法检测极限).
- 证明了出色的线性 (R2>0.99),回收率 (70-130%) 和精度 (RSD ≤20%).
- 在各种水表中量化EC,在废水流入中含量最高,在饮用水/自然水中含量微量.
结论:
- 开发的LC-MS/MS方法是稳固的,敏感的,适合用于39个EC的例行监测.
- 该方法在监管合规,来源追踪和风险评估方面具有强大的实用性.
- 适度的环境可持续性和广泛的化学覆盖范围使其对环境分析具有价值.
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