心率变化的神经调节:一个系统的审查
Rodrigo Souza1, Irinaldo Capítulino de Souza1, Suellen Mary Marinho do Santos Andrade2
1Graduate Program in Decision Models and Health, Center for Exact and Natural Sciences, Federal University of Paraíba, Brazil.
Autonomic neuroscience : basic & clinical
|January 8, 2026
概括
非侵入性神经调节,如间直流刺激 (tDCS) 和皮间迷走神经刺激 (tVNS),对心率变化 (HRV) 没有显著影响. 需要更多的标准化研究来确认它们对自主神经系统功能的影响.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 医疗技术 医疗技术 医学技术
背景情况:
- 自主神经系统 (ANS) 功能障碍增加了心血管事件的风险.
- 非侵入性神经调节 (tDCS,TMS,tVNS) 的目的是调节ANS.
- 由于研究异质性,这些方法的比较疗效和最佳方案尚不清楚.
研究的目的:
- 系统地审查和元分析tDCS,TMS和tVNS对心率变化 (HRV) 的影响的证据.
- 通过这些神经调节技术来评估交感静脉平衡调节.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 搜索的主要数据库 (科克兰,科学网,PubMed,Embase) 到2024年10月.
- 包括随机对照试验 (RCT),比较tDCS,TMS或tVNS与HRV结果的假状况.
主要成果:
- 包括13个RCT (5个tDCS,6个tVNS,2个TMS),并指出了显著的协议异质性.
- 分析显示,tDCS或tVNS对HRV (频率或时间域变量) 没有统计学上显著的影响.
- 对于tDCS和tVNS,主要结果的证据质量被评为中度.
结论:
- 目前关于tDCS,TMS和tVNS对HRV的影响的证据有限且异质.
- 强调需要在神经调节协议中的方法标准化.
- 需要更大的样本大小研究才能获得更强大的ANS调节的临床发现.
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