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新兴的病毒蛋白,RBP动态和骨重塑:针对双重抗病毒和骨保护疗法的液体-液体相分离

Ying Huai¹, Xue Wang¹, Jingchuan Yan¹

¹Advance Spine Surgery Center, Department of Orthopedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710038, PR China.

Molecular aspects of medicine

|January 8, 2026

概括

像SARS-CoV-2这样的病毒通过操纵细胞液体-液体相分离 (LLPS) 和RNA结合蛋白 (RBPs) 来破坏骨健康. 这次审查提出了一个

科学领域:

病毒学病毒学
分子生物学分子生物学
骨生物学骨生物学

背景情况:

新兴病毒 (SARS-CoV-2,ZIKV,CHIKV) 导致重大公共卫生问题,包括骨疾病和关节痛.
连接病毒感染与骨质平衡破坏的细胞内机制尚不清楚.
液体-液体相分离 (LLPS) 和RNA结合蛋白 (RBPs) 都与病毒病原发生有关.

研究的目的:

审查LLPS和RBPs在病毒引起的骨并发症中的作用.
为后病毒性肌肉骨疾病提出统一的"双击"病原性框架.
识别治疗策略的知识差距和转化机会.

主要方法:

对病毒性LLPS,RBP功能障碍和骨质生成信号的当前文献的综述.
分析SARS-CoV-2核体蛋白在通过LLPS抑制宿主压力颗粒中的作用.
将发现整合到一个连贯的病原体模型中.

主要成果:

病毒蛋白操纵LLPS破坏宿主抗病毒机制 (压力颗粒).
这种干扰会影响RBP稳定性 (例如,HuR),损害β-catenin的核定位,并抑制Wnt介导的骨质生成.
一个"双击"框架将病毒性LLPS,RBP功能障碍和受损的骨重塑联系起来.

结论:

对LLPS和RBPs的病毒操纵有助于病毒后骨疾病.
关键的知识缺口包括缺乏临床验证和对LLPS相关骨问题的体内证据.
针对病毒-宿主相接口提供了对抗病毒作用和恢复骨质生成信号的双重治疗潜力.

关键词:

新出现的病毒.液体-液体相隔离 (LLPS) 是一种液体相隔离技术.骨质发生过程 (osteogenesis)有关RNA结合的蛋白质.病毒素是一种病毒素.

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