相关实验视频

Updated: Jan 13, 2026

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)

Published on: June 27, 2025

针对细菌的双锁传递用于结直肠癌中闭环免疫调节

Youtao Xin¹, Hegang Lu¹, Jingwen Zhao²

¹National Key Laboratory of Advanced Separation Membrane Materials & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) & Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China.

Journal of controlled release : official journal of the Controlled Release Society

|January 8, 2026

概括

这项研究引入了一种新型的细胞系统,该系统可以提供药物来消除细菌并重塑瘤微环境,通过改善T细胞透和免疫记忆来增强结直肠癌免疫疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物材料科学生物材料科学

背景情况:

杆菌核菌的殖民化和树膜壁垒阻碍了T细胞的透,限制了结直肠癌免疫疗法的有效性.
需要一个闭环策略,通过解决细菌负载和瘤微环境来恢复抗瘤免疫力.

研究的目的:

开发一种生物响应的联合组装聚合物微粒 (CPM-GalNAc) 用于向性联合输送皮醇 (Cal) 和鸟醇 (ONZ).
通过重塑细胞外基质 (ECM) 和根除内细菌来实现闭环免疫调节.
为了提高结直肠癌 (CRC) 免疫疗法的疗效.

主要方法:

开发了一种双药联合体 (Cal-ONZ) 封装在CPM-GalNAc微粒中,以改善负载.
采用双锁设计,用于pH响应药物释放和特定细菌向.
研究了ONZ (细菌根除) 和Cal (ECM重塑) 对T细胞透和抗瘤免疫的协同作用.

主要成果:

该 Cal-ONZ 结合剂提高了药物封装效率.
CPM-GalNAc菌株表现出pH响应的释放和向的F.核清除.
结合疗法增强了细胞毒性T细胞的招募,抑制了与癌症相关的纤维细胞,破坏了ECM,并促进了更深的T细胞透.
该策略增强了αPD-L1检查点阻塞的有效性,并建立了持久的免疫记忆.

结论:

开发出来的生物响应性菌根为强化结直肠癌免疫治疗提供了一个有前途的战略.
这种方法有效地恢复抗瘤免疫力,同时针对细菌和瘤微环境.
闭环免疫调节策略具有防止瘤复发的潜力.

关键词:

与癌症相关的纤维细胞.结肠直肠癌是一种癌症.免疫治疗是一种免疫疗法.瘤内细菌是一种细菌.聚合物微粒是多重的

更多相关视频

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...