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提高黄素的生物可用性,使用双功能周期性半孔性有机来提供pH响应性抗癌药物
Sedigheh Abedanzadeh1, Babak Karimi2, Omid Pourshiani2
1Faculty of Chemistry, Kharazmi University, Tehran, 15719-14911, Iran; Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
Nanomedicine : nanotechnology, biology, and medicine
|January 8, 2026
概括
双功能周期性半孔性有机 (BFPMO) 增强了黄素的输送,提高了抗癌疗效和生物可用性. 这种生物相容的纳米载体显示出pH响应的释放和对正常细胞的毒性降低.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 黄素具有较差的生物利用性和稳定性,限制了其治疗潜力.
- 开发有效的药物输送系统对于提高黄素抗癌效果至关重要.
研究的目的:
- 为了合成和描述双功能周期性半孔性有机 (BFPMO) 作为黄素的纳米载体.
- 为了评估在体外抗癌疗效,生物可用性和素载体BFPMO (CUR@BFPMO) 的pH响应释放.
主要方法:
- 使用N2吸附-脱附,FT-IR,TGA,HRTEM,FESEM和EDAX进行BFPMO的合成和表征.
- 在不同的pH条件下进行体外药物加载,封装效率,稳定性和释放研究.
- 细胞活力测试 (HEPG2,A2780,NIH-3T3),流细胞计和光成像,以评估抗癌活性和亡诱导.
主要成果:
- BFPMO成功地封装了高负荷 (60%) 和封装效率 (88%) 的黄素.
- CUR@BFPMO证明了改善的黄素稳定性,pH响应释放,以及良好的血红相容性.
- CUR@BFPMO显著降低了癌细胞活力,同时对正常细胞的毒性较低,诱导了时间依赖的亡.
结论:
- BFPMO作为一个有前途的生物相容纳米载体,用于黄素的输送.
- 开发的系统增强了黄素的生物可用性,提供了pH响应的释放,并提高了抗癌疗效.
- 基于BFPMO的黄素输送具有针对性癌症治疗的潜力,并减少了副作用.
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