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相关概念视频

Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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Volatilization gravimetry is an analytical technique that measures the mass lost due to the volatilization of the substance. This technique is used to estimate the amount of volatile material in a sample. To perform this method, heat a known amount of the sample to a high temperature in a crucible or other suitable vessel. The volatile substance in the sample evaporates, and the vapor is completely expelled from the crucible either by heating the sample or bubbling a stream of inert gas through...
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O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression
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在流体化床干燥过程中对颗粒的水分含量进行定量分析,同时使用近红外和拉曼光谱学,并与多变量模型相结合.

Chuanchuan Li1, Weiping Zhu1

  • 1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China.

International journal of pharmaceutics
|January 8, 2026
PubMed
概括

与拉曼光谱相比,近红外 (NIR) 光谱与部分最小平方 (PLS) 模型为在流化床干燥 (FBD) 期间监测颗粒含水量提供了更高的准确性,从而可以精确地确定终点.

关键词:
A. 液床干燥是一种流体干燥.B. 颗粒物中的水分.C.近红外光谱学近红外光谱学D. 拉曼光谱法 拉曼光谱法E. 化学测量 化学测量F. 过程监控 过程监控

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科学领域:

  • 制药制造业 制药制造业 制药制造业
  • 过程分析技术 (PAT) 是一种分析技术.
  • 频谱学是一种光谱学.

背景情况:

  • 有效监测颗粒含水量 (MC) 对于液化床干燥 (FBD) 的质量控制至关重要.
  • 精确确定干燥终点可确保制药制造中的产品质量和工艺效率.
  • 传统方法可能耗时,需要先进的技术进行实时分析.

研究的目的:

  • 将近红外 (NIR) 和拉曼光谱进行比较,用于在基酸盐 (HCQ) FBD期间监测颗粒MC.
  • 评估化学测量模型 (PLS,SVM) 和用于MC测定的光谱预处理技术的性能.
  • 为实时过程理解和干燥端点检测建立一个综合方法.

主要方法:

  • 在大型HCQ制造过程中获得的NIR和拉曼光谱数据的比较分析.
  • 使用部分最小平方 (PLS) 和支持向量机 (SVM) 回归的校准模型的开发.
  • 应用各种光谱预处理技术 (SNV,MSC,SG,ND,衍生品,OSC) 来提高模型的准确性.

主要成果:

  • 与PLS相结合的NIR光谱学证明了MC监测的优异预测性能 (R2p=0.9990,RMSEP=0.105).
  • 使用SVM的拉曼光谱显示出良好的性能 (R2p=0.9600,RMSEP=0.474),但精度低于NIR.
  • 在线拉曼光谱为NIR结果提供了外部验证,提高了对MC分析的信心.

结论:

  • 在线NIR光谱,与湿度/温度数据记录器集成,提供FBD的实时过程理解.
  • 这种综合方法可以准确快速地确定干燥终点,通常在1.5%至2.5%MC之间.
  • 该研究验证了先进的光谱技术的使用,以在制药干燥过程中进行强有力的质量控制.