设计和评估双功能的阿巴胺-联体作为向癌症治疗的平台
Simona Marzano1, Maria Grazia Ferraro2, Nicola Grasso1
1Department of Pharmacy, University of Naples Federico II, Naples, 80131, Italy.
概括
这项研究开发了用于癌症治疗的新型阿巴-联体. 一种结合剂通过将向传递与协同效应相结合,显示出增强的抗瘤活性.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 纳米技术 纳米技术
背景情况:
- AS1411是一种富含G的DNA受体,向核素,核素是癌细胞中过度表达的蛋白质.
- AS1411可以促进治疗药物的输送,而细胞吸收较差,例如亲细胞 KLA.
- 开发向癌症治疗需要创新的药物输送系统.
研究的目的:
- 设计和合成AS1411-KLA结合物使用应变促进的亚酸-基环添加化学.
- 为了结合蛋白酶可切割的链体,用于细胞内释放活跃的和.
- 为了评估这些阿巴美尔-联体在癌细胞中的治疗潜力.
主要方法:
- 合成AS1411-KLA结合物与蛋白酶可切割的链接剂.
- 循环二重化谱法以确认G-四重复结构的保存.
- 表面等离子体共振来评估核素结合亲和力.
- 在MCF-7乳腺癌细胞和MCF-10A细胞中的体外生物评估.
主要成果:
- AS1411-KLA合物保留了AS1411的特征G四重复结构.
- 所有的结合物都证明了持续与核结合.
- 与单个成分相比,一个合物表现出明显增强的抗增殖作用.
- 结合剂的设计是为了细胞内释放和.
结论:
- 阿普塔默-联体是下一代向癌症治疗的有希望的策略.
- 这种模块化设计允许有针对性的交付和协同的治疗行动.
- 开发的结合剂有可能提高癌症治疗的疗效.
更多相关视频
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
6.5K
11:58Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
Published on: March 8, 2018
8.0K
相关概念视频
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:50Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K