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开发和体外/体外评估聚合物溶解微针配方用于治疗牛皮
Meryem Kaplan1, Fatma Betül Arslan2, Süleyman Can Öztürk3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, 06100, Ankara, Turkiye; Department of Pharmaceutical Technology, Faculty of Pharmacy, Süleyman Demirel University, 32260, Isparta, Turkiye.
概括
装有IL-17A抑制剂secokinumab的微针可以有效治疗牛皮. 这种方法增强局部药物输送,在炎症性皮肤疾病中获得更好的治疗结果.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 生物材料科学 生物材料科学
背景情况:
- 牛皮是一种慢性自身免疫性皮肤疾病,有效治疗方法有限.
- 传统疗法在有效性,耐受性,安全性和成本方面面临挑战.
- 针对免疫机制的基于生物的疗法显示出改善疾病控制和生活质量的前景.
研究的目的:
- 调查微针作为皮肤间药物输送系统用于牛皮治疗.
- 为了评估装有secukinumab (IL-17A抑制剂) 和Stattic (STAT3抑制剂) 的微针的疗效.
- 评估增加局部药物度和改善治疗结果的潜力.
主要方法:
- 生物相容的溶解微针的制造,通过微型成型使用氨酸和糖.
- 用secukinumab和/或Stattic.com加载微针.
- 在体外表征和细胞培养研究.
- 建立了牛皮的小鼠模型.
- 通过监测病变进展和组织学检查,对治疗效果的体内评估.
主要成果:
- 装有secukinumab的微针在降低剂量的情况下显示出更有效的治疗效果.
- 通过微针进行局部输送可能会增加牛皮斑中的药物度.
- 组织学检查证实了对病变进展的治疗作用.
结论:
- 溶解装有secukinumab的微针是局部牛皮治疗的一个有希望的策略.
- 与传统方法相比,这种方法有可能提高疗效和降低剂量.
- 对于自身免疫性皮肤疾病,对联合疗法和微针输送系统的进一步研究是有必要的.
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