在日本,对抗抗卡巴胺耐药的格拉姆阴性病原体的 cefiderocol 的体外活性
Kenjiro Matsui1, Aki Sakurai2, Yasufumi Matsumura3
1Department of Clinical Laboratory, Fujita Health University Hospital, Toyoake, Aichi, Japan.
概括
在日本,Cefiderocol显示出强烈的体外活性,对抗抗卡巴胺的格拉姆阴性细菌 (CRGNB),包括金属β-乳糖酶生产者. 建议在怀疑耐药性时进行汁微稀释测试以确认.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 耐卡巴胺的格拉姆阴性细菌 (CRGNB) 构成了严重的全球健康威胁.
- CRGNB的出现需要对新型抗菌剂进行评估.
- 这项研究重点研究了 cefiderocol 和较新的β-lactam/β-lactamase 抑制剂组合的体外活性.
研究的目的:
- 评估 cefiderocol 与临床相关CRGNB的体外疗效.
- 为了比较Cefiderocol与其他最近批准的药物的活性.
- 为了评估盘扩散的性能,用于对 cefiderocol 敏感性测试.
主要方法:
- 对来自日本的292个CRGNB临床分离物 (Enterobacterales,Pseudomonas aeruginosa,Stenotrophomonas maltophilia) 的分析.
- 使用微稀释 (BMD) 和磁盘扩散的抗微生物敏感性测试.
- 全基因组测序 (WGS) 用于物种确认和耐药性决定因素的识别.
主要成果:
- 在所有CRGNB中,包括金属β-乳糖酶 (MBL) 生产商中,Cefiderocol表现出高敏感率 (94.5%).
- 塞菲德罗科尔对肠杆菌 (91.8%),P. aeruginosa (99.1%) 和S. maltophilia (92.5%) 显示出强烈的活性.
- 磁盘扩散测试显示与BMD有很好的一致性,尽管建议确认BMD.
结论:
- 在日本,Cefiderocol对广泛的CRGNB具有显著的体外活性.
- 这种药物对产生MBL的菌株特别有效.
- 在临床上怀疑耐药性时,建议对Cefiderocol进行微稀释测试.
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