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Updated: Jan 13, 2026

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骨髓缩症与中国社区老年人轻度认知障碍有关
Peipei Han1, Pingping Cai2, Yuechao Sun3
1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China; College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Journal of the American Medical Directors Association
|January 8, 2026
概括
骨质疏松症和麻症的结合显著增加了老年人轻度认知障碍 (MCI) 的风险. 这种协同效应凸显了在社区环境中解决认知健康的两个条件的重要性.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 骨质疏松症和肉症是常见的与年龄有关的疾病.
- 轻度认知障碍 (MCI) 在老年人群中越来越令人担忧.
- 骨健康,肌肉质量和认知功能之间的相互作用需要进一步调查.
研究的目的:
- 调查骨质疏松症和肉症的同时发生与轻度认知障碍 (MCI) 的流行之间的关联.
- 检查骨质疏松症和肉病对中国老年人认知状态的独立和联合影响.
主要方法:
- 一项涉及上海1058名社区老年人 (≥65岁) 的横截面研究.
- 骨质疏松症通过前臂骨双能X射线吸收计 (T-score ≤ -2.5) 诊断.
- 使用2019年亚洲肉类症工作组 (AWGS) 标准诊断出肉类症.
- 使用微型精神状态检查 (MMSE) 和日常生活工具活动 (IADL) 尺度评估MCI.
主要成果:
- 在正常群体中,MCI的患病率为9.0%,仅在骨质疏松症中为11.1%,仅在骨质疏松症中为22.7%,在同时发生的骨质疏松症和骨质疏松症组中为28.3%.
- 骨质疏松症和肉症的同时发生显示,与单独的肉症相比,MCI的患病率显著更高 (OR,4.00) (OR,2.99).
- 在调整了混因素后,骨质疏松症和肉症的联合存在仍然是与增加MCI患病率相关的唯一统计学上显著的因素 (OR,2.29).
结论:
- 骨质疏松症和肉症都没有独立预测MCI在这个队列中的患病率.
- 骨质疏松症和肉症的同时发生,协同增加了中国社区老年人中MCI的流行率.
- 这些发现强调了骨和肌肉健康的综合管理策略的重要性,以潜在地减轻老龄化人口的认知衰退.
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