核医学和前列腺癌的外部束辐射疗法:一种协同的方法
May Abdel-Wahab1, Francesco Giammarile2
1Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
概括
将放射性药物治疗 (RPT) 与外部光束放射治疗 (EBRT) 结合起来,为前列腺癌提供了一个强大的新策略. 这种方法通过针对可见和显微的疾病来增强瘤控制和患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 辐射疗法 辐射疗法
背景情况:
- 放射性药物治疗 (RPT) 结合外部光束放射治疗 (EBRT) 是前列腺癌的新兴治疗策略.
- 这种组合利用EBRT用于可见瘤和RPT用于显微或系统性疾病,基于历史的89Sr试验.
- 临床和临床前数据表明,改善了瘤控制,缓解疼痛和生活质量,毒性可控.
研究的目的:
- 审查前列腺癌治疗中联合RPT和EBRT的现有证据和未来方向.
- 突出高级成像,特别是前列腺特异性膜抗原 (PSMA) PET 在患者选择和治疗规划中的作用.
- 讨论PSMA向RPT的潜力,如177Lu-PSMA,在改善转移性割抵抗性前列腺癌的结果.
主要方法:
- 对联合RPT和EBRT的临床和临床前证据的审查.
- 强调PSMA PET成像在疾病映射和治疗规划中的作用.
- 讨论PSMA向性RPT及其在转移性割抵抗性前列腺癌中的应用.
主要成果:
- 结合RPT和EBRT表明增强瘤控制,缓解疼痛和提高生活质量.
- 针对PSMA的RPT,包括177Lu-PSMA,在转移性割抵抗性前列腺癌中显示出整体生存益处.
- 像PSMA PET这样的先进成像对于精确的治疗策略至关重要.
结论:
- 结合RPT和EBRT是个性化前列腺癌护理的一个有前途的方法.
- 目前正在进行的试验正在探索并发/序列策略和α-发射器放射体,以进一步提高生存率.
- 应对后勤方面的挑战将有助于将RPT和EBRT组合整合到标准治疗范例中.
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