[cGAS-STING轴在痛风性关节炎中介于NETs形成的机制]

Yue Tan1, Xingrui Li2, Tong Liu1

  • 1Department of Rheumatology and Immunology, Lu'an People's Hospital (also known as The Affiliated Lu'an Hospital of Anhui Medical University), Lu'an 237000, China.

概括

单酸盐晶体通过激活干扰素基因 (cGAS-STING) 循环GMP-AMP合成酶刺激器通路来促进痛风性关节炎,从而导致中性粒细胞外陷 (NET) 形成和炎症. 准这种cGAS-STING通路为痛风性关节炎提供了一个潜在的治疗策略.

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