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Updated: Jan 13, 2026

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在健康的大脑和多发性硬化症大脑中的T细胞

Joost Smolders1, Cheng-Chih Hsiao2, Inge Huitinga3

  • 1Neuroimmunology Research Group, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands; MS Center ErasMS, Departments of Neurology and Immunology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.

Trends in immunology
|January 8, 2026
PubMed
概括

人类大脑T细胞是具有独特特性的组织内存细胞. 这些发现增强了对中枢神经系统 (CNS) 免疫监测和T细胞在多发性硬化症等疾病中的作用的理解.

关键词:
中枢神经系统中枢神经系统多发性硬化症多发性硬化症组织居住地 组织居住地

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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