认知训练对神经认知障碍患者皮质醇水平的影响
Marina De Rui1, Giulia Salerno Trapella1, Chiara Ceolin1,2
1Department of Medicine (DIMED), University of Padua, Padua, Italy.
概括
认知训练 (CT) 可能有助于降低神经认知障碍 (NCD) 患者的皮质醇水平. 这种非药物治疗方法显示了调节应激反应的潜力,补充了现有的治疗方法.
科学领域:
- 神经内分泌学神经内分泌学
- 认知神经科学 认知神经科学
- 老年学是一门学科.
背景情况:
- 皮质醇升高与神经认知障碍 (NCD) 的风险增加和进展有关.
- 像运动和正念这样的干预措施可以降低皮质醇,但认知训练 (CT) 的效果是未知的.
- 皮质醇失调与认知能力下降有关.
研究的目的:
- 研究认知训练 (CT) 对非传染性疾病患者皮质醇水平和分泌模式的影响.
- 为了比较CT对皮质醇调节的效果与NCD患者的药理治疗 (PH).
主要方法:
- 招募了62名患有非传染性疾病的老年人和43名健康对照人群.
- 患者被分为CT (n=34) 和PH (n=28) 组.
- 唾液皮质醇在基线和干预后3个月和6个月的6个每日时间点被测量.
主要成果:
- 与PH相比,CT显示每日皮质醇AUC的百分比下降更大,尽管在调整后没有统计学意义.
- 在下午的皮质醇水平 (p=.028) 中观察到显著的时间点效应.
- 在两组中,早晨皮质醇水平都下降了,但皮质醇唤醒反应 (CAR) 的差异在两组之间并不显著.
结论:
- 认知训练可能提供一种非药理学策略,以降低NCD患者的皮质醇水平并改善NCD患者的认知功能.
- CT显示了调节下丘脑-垂体-上腺轴活动的潜力.
- 需要进行更大的随机对照试验来验证这些发现.
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