邻居的Voxelwise相关性作为一个由假设驱动的框架来描述白质病变异质的特征
Mohamad J Alshikho1,2,3, Patrick J Lao1,2,3, Natalie C Edwards1,2,3
1Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P&S Box 16, New York, NY, 10032, USA.
邻居的Voxel-wise关联 (VCON) 提供了一种新方法来分析脑MRI扫描中的白质超强度 (WMH). 这种方法揭示了标准二进制细分错过的微结构损伤变异,改善了脑血管疾病的特征.
科学领域:
- 神经成像是一种神经成像.
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
背景情况:
- 白质超强度 (WMH) 在衰老中很常见,并与脑血管疾病有关.
- 目前的MRI细分方法将WMH视为统一的二进制病变,失去详细信息.
- 更丰富的表征需要结合流体减弱反转恢复 (FLAIR) 和扩散核磁共振.
研究的目的:
- 介绍Voxel-wise邻居相关性 (VCON),这是一个新的跨模式框架.
- 在个体内量化FLAIR强度和分数异构性 (FA) 之间的声素级关系.
- 产生基于假设的WMH标签,反映潜在的微观结构损伤.
主要方法:
- 开发了VCON,一个使用T2加权FLAIR和扩散MRI的交叉模式框架.
- 个体内的量化声素水平强度和FA相关性.
- 用超过2500名参与者在老龄化队列中的数据验证了VCON.
主要成果:
- VCON确定了WMH区域,增加了与FA负相关的FLAIR信号,表明微观结构损伤.
- 多尺度分析,年龄关联建模和扫描器比较验证了VCON.
- WMH被分为具有明显微观结构配置的区域,显示梯度跟踪年龄和扩散指标.
结论:
- 二元WMH细分掩盖了临床上重要的病变特征变异.
- VCON重新定义了细分作为微观结构异质性的特征.
- 这种多式联络方法提供了超越传统方法的增强,结构信息化的表征.
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