对于选择动态和由抗生素驱动的新型耐药性演变的甲化物耐受性的后果
Orestis Kanaris1, Lydia-Yasmin Sobisch1, Annett Gödt1
1Division of Biodeterioration and Reference Organisms (4.1), Department of Materials and the Environment, Federal Institute for Materials Research and Testing (BAM), Berlin, Germany.
npj antimicrobials and resistance
|January 8, 2026
概括
在大肠杆菌中对甲 (BAC) 的耐受性可以在低度下促进对甲的耐药性. 然而,BAC耐受性可能会限制对其他抗生素耐药性的演变.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 诸如化 (BAC) 这样的杀菌剂被广泛使用,诸如大肠杆菌 (Escherichia coli) 这样的细菌可以产生耐受性.
- 以前的研究表明,BAC耐受性会影响抗生素敏感性,但其对抗生素耐药性演变的影响尚不清楚.
研究的目的:
- 研究甲 (BAC) 耐受性如何影响大肠杆菌对各种抗生素的进化反应.
- 了解在联合BAC和抗生素压力下选择动态和耐药性演变.
主要方法:
- 在不同的抗生素度下,竞争试验比较了BAC耐受性和BAC敏感性大肠杆菌菌株.
- 实验室进化实验涉及连续转移以评估抗性发展.
- 分析BAC耐受性突变和抗生素耐药性突变之间的遗传相互作用,包括表现症.
主要成果:
- 齐普罗夫洛克萨的抑制度选择性地有利于耐受BAC的大肠杆菌菌株.
- 在较高的抗生素度下,BAC敏感菌株比BAC耐受菌株更容易对西普罗夫洛克萨,胆素和仁友素产生耐药性.
- BAC耐受性突变和 ompF淘汰突变之间的表皮相互作用部分解释了耐受性菌株中对西普罗夫洛克萨辛耐药性的降低演变能力.
结论:
- 在度低的环境中,可以保持BAC耐受性.
- BAC耐受性似乎限制了进化途径,导致对某些抗生素的耐药性,可能是通过限制遗传变异或通过表皮性相互作用.
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