帕金森病的动态 thalamocortical 功能连接性障碍,可能有 REM 睡眠行为障碍
Shidong Tan1,2, Yichi Zhang3, Mengyue Niu3
1Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Scientific reports
|January 8, 2026
概括
在患有快速眼动睡眠行为障碍 (RBD) 的帕金森病 (PD) 患者中,动态功能连接性障碍与疾病严重程度有关. 这些甲状腺皮层变化可能作为PD中RBD的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 在帕金森病 (PD) 中,快速眼动睡眠行为障碍 (RBD) 的阳性症状表明,thalamic亚核和皮质之间的动态功能连接 (FC) 受到干扰.
- 了解这些干扰对于识别潜在的生物标志物和了解PD进展至关重要.
研究的目的:
- 在帕金森病 (PD) 患者中,在有或没有可能的快速眼动睡眠行为障碍 (RBD) 患者中,调查thalamic核和皮质区域之间的动态功能连接 (FC) 的变化.
- 探索这些动态FC变化与RBDPD患者的PD临床严重程度之间的相关性.
主要方法:
- 功能磁共振成像 (fMRI) 扫描对35名PD患者进行了可能的RBD (PD-pRBD),40名PD患者没有可能的RBD (PD-npRBD) 和41名健康对照.
- 计算和分析了14个双边乳头核和皮质区域之间的动态FC.
- 进行了临床评估,并检查了动态FC和PD严重程度之间的相关性.
主要成果:
- 患有PD-pRBD的患者在特定的乳头核 (中背侧侧细胞,脉侧侧) 和小脑/皮层区域之间表现出更大的FC波动.
- 患有PD-npRBD的患者在脉动中枢核和状叶片之间显示出较高的动态FC.
- 在PD-pRBD患者中,双边中脊侧侧侧细胞核和小脑前叶的动态FC与临床严重性之间发现了积极的相关性.
结论:
- 改变的动态 thalamocortical 功能连接性与帕金森病 (PD) 的快速眼动睡眠行为障碍 (RBD) 有关.
- 这些动态的FC变化可以作为潜在的生物标志物来监测PD中RBD的发热性质.
- 建议通过多睡眠学验证进行进一步的研究,以精确确定PD中RBD严重程度的表型.
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