在急性初级角度关闭后长期视神经头部微血管损伤:一项OCTA研究
Yue Ying1,2,3, Xintong Fan1,2,3, Yanan Sun1,2,3
1Eye Institute, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Rd., Shanghai, 200031, China.
概括
长期来看,与健康的眼睛相比,解决了急性初级角度闭合 (APAC) 的眼睛显示出周周血管密度 (VD) 的降低. 在初始治疗后,视神经头部区域的长期微血管变化仍然存在.
科学领域:
- 眼科医生 眼科 眼科
- 微血管成像技术 微血管成像技术
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 急性初级视角闭合 (APAC) 可以导致暂时的视力丧失.
- 之前的研究指出,亚太地区后的底层血管密度 (VD) 暂时下降.
- APAC对视神经头部 (ONH) 和黄斑微血管的长期影响仍然不太清楚.
研究的目的:
- 为了研究长期的微血管变化,特别是血管密度 (VD),在视神经头部 (ONH) 和急性初级角度关闭 (APAC) 后的斑点.
- 为了确定特定的解剖区域,在亚太地区解决方案后很长一段时间内表现出减少的VD.
主要方法:
- 使用光谱域光学连贯性断层扫描血管学 (OCTA) 进行定量微血管评估.
- 包括已解决的APAC眼睛,主要角度闭合嫌疑人 (PACS) 和健康的对照.
- 作为主要终点,对周毛囊性VD进行分析,以部门ONH VD和黄斑性VD作为次要措施.
主要成果:
- 与PACS和对照组相比,有APAC病史的眼睛表现出明显较低的周周毛囊VD.
- 亚太地区发病和检查之间的间隔为1至60个月 (中位数为15个月).
- 黄斑性VD受到先前的APAC的影响较小,而ONH VD与结构参数相关.
结论:
- 在有APAC史的眼睛中,周周血管密度仍然显著降低,即使在临床解决之后.
- 这些发现突显了APAC之后视神经头部区域持续的微血管变化.
- 长期监测微血管变化可能与眼睛的管理有关,有角关闭的历史.
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