慢性鼻炎优化鼻腔结果和得分 (CHRONOS):意大利德尔菲关于生物药物长期管理的共识
Eugenio De Corso1, Frank Rikki Mauritz Canevari2,3, Marco Caminati4,5
1Unit of Otorhinolaryngology and Head-Neck Surgery, A Gemelli University Hospital Foundation IRCCS, Rome, Italy.
Current allergy and asthma reports
|January 8, 2026
概括
长期的生物疗法有效地管理严重的慢性鼻炎与鼻息肉 (CRSwNP),提供持续控制和潜在的疾病修饰. 个性化剂量和联合评估方法是优化CRSwNP患者治疗结果的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的带鼻息肉的慢性鼻炎 (CRSwNP) 给长期管理带来了重大挑战.
- 2型炎症是CRSwNP发病的一个关键驱动因素.
- 针对2型炎症的生物药物已经成为一个有前途的治疗选择.
研究的目的:
- 综合证据和专家对生物药物长期管理CRSwNP的共识.
- 根据意大利的CHRONOS项目,为优化生物治疗提供实际指导.
- 审查生物药物在CRSwNP中的有效性,安全性和疾病修饰潜力.
主要方法:
- 审查当前证据和专家共识.
- 临床试验和现实世界关于CRSwNP的生物疗法的数据分析.
- 纳入意大利CHRONOS项目的发现.
主要成果:
- 生物药物在控制CRSwNP和实现缓解方面表现出持续的有效性和安全性.
- 个性化剂量和剂量间隔策略是可行的和有效的.
- 综合主观和客观测量,包括嗅觉测试,对于反应评估至关重要.
- 在某些特定情况下,生物药物可能被认为是手术前的药物,并显示出疾病修饰的潜力.
结论:
- 长期的生物治疗为许多CRSwNP患者提供了持久的控制和缓解.
- 优化,个性化治疗方案和多学科监督是必不可少的.
- 生物药物在改变严重CRSwNP的自然史方面取得了重大进展.
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
719
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
719
01:17Drugs Used in Lower Respiratory Disorders: Overview
1.0K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.0K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K
01:23Chronic Pharyngitis
10.8K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
10.8K
01:16Drugs Used in Upper Respiratory Disorders: Overview
619
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
619
01:30Epistaxis
510
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
510