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红氧驱动的ADAR1激活促进了奥卡扎基片段的成熟和DNA复制完整性

Bin Chen1,2, Guangchao Sun3, Jake A Kloeber1,4

  • 1Department of Oncology, Mayo Clinic, Rochester, MN, USA.

Nature structural & molecular biology
|January 8, 2026
PubMed
概括

反应性氧物种 (ROS) 触发了一种依赖于氧化还原的机制,涉及ADAR1介导的RNA编辑以纠正不匹配的原料. 这确保了高效的Okazaki碎片成熟和复制叉稳定性.

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