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Updated: Jan 13, 2026

Self-Administration of Drugs in Mouse Models of Feeding and Obesity
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虚拟双胞胎-PBPK建模:向肥胖患者的精确剂量定量迈出了一步

Haribhau Kangne1, Nihan Izat1, Gong Chen1

  • 1Division of Pharmacy and Optometry, School of Health Sciences, Centre for Applied Pharmacokinetic Research, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

The AAPS journal
|January 8, 2026
PubMed
概括

虚拟双胞胎生理学基础的药理动力学 (VT-PBPK) 模型准确地预测肥胖症中的药物水平. 这种方法对优化肥胖人口中个体药物剂量有希望.

关键词:
PBPKK PBPK 的意思是什么意思消毒素 (Digoxin) 是一种消毒剂.米达佐拉姆 (Midazolam) 是一种药物.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖虚拟双胞胎是一个虚拟的双胞胎.

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