用丹诺苏马布治疗骨质疏松症的牙科植入物相关的MRONJ风险:系统性审查
Rebheca Maria Pereira Santos1, Giulia Ottaviani1,2, Roberto Di Lenarda1,2
1Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Oral diseases
|January 8, 2026
概括
接受德诺苏马布治疗的骨质疏松症患者的牙科植入物很少会导致与药物相关的骨缩 (MRONJ). 诸如治疗过渡和植入时间等因素会影响风险,但需要更多的研究.
科学领域:
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
- 骨质疏松症管理管理
背景情况:
- 用德诺苏马布治疗骨质疏松症会增加与药物相关的骨硬化 (MRONJ) 的风险.
- 接受德诺苏马布治疗的患者的牙科植入物安全性是一个日益关注的问题,有可能导致植入物外科手术引发的骨硬化 (ISTO) 和植入物存在引发的骨硬化 (IPTO).
研究的目的:
- 系统地审查现有的关于牙科植入物对骨质疏松症患者治疗denosumab的MRONJ发育的影响的文献.
- 为了确定影响MRONJ风险的因素,在这个患者群体.
主要方法:
- 使用PICO框架进行了全面的电子文献搜索.
- 选择了10项研究,包括案例系列,队列研究,病例对照研究和随机对照试验,用于质量评估和数据提取.
主要成果:
- 选择的研究显示出显著的异质性,小样本大小和缺乏标准化.
- 在这种情况下,发现与药物相关的骨 (MRONJ) 是相对罕见的.
- 确定的主要影响因素包括从双酸盐过渡到德诺苏马布,牙植入物安置的时间,以及围部植入炎的存在.
结论:
- 由于研究异质性,关于在denosumab治疗患者中的牙科植入物和MRONJ的最终结论是有限的.
- 尽管这种情况很罕见,但对治疗过渡,植入时间和植入周围健康的仔细考虑对于管理风险至关重要.
- 进一步的标准化研究是必要的,以更好地了解和减轻 MRONJ 在这个人群中的风险.
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