[一种来自Euphorbia thymifolia的具有抗炎活性的新型亚特罗二甲]
Yang-Yang Liu1, Chang-He Liang2, Jiang-Ying Cao2
1College of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250355, China Shandong Co-Innovation Center of Classic Traditional Chinese Medicine Formula (Shandong University of Traditional Chinese Medicine) Ji'nan 250355, China.
概括
研究人员从Euphorbia thymifolia中分离出了10种化合物,其中包括一种新的贾特罗类型的迪特尔化物. 这种新化合物在细胞测试中显示出氧化 (NO) 抑制活性.
科学领域:
- 植物化学 植物化学
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 优草 (Euphorbia thymifolia) 是一种具有传统使用历史的药用植物.
- 迪特尔类和类是众所周知的各种生物活动的自然产品类.
研究的目的:
- 从Euphorbia thymifolia的上空部分中分离和描述化学成分.
- 评估分离化合物的潜在生物活性.
主要方法:
- 使用色谱技术 (MCI,ODS,HPLC) 进行提取和分离.
- 通过光谱方法 (UV,IR,NMR,MS) 阐明结构.
- 在体外测试,检测LPS诱导的BV-2细胞中氧化 (NO) 抑制活性.
主要成果:
- 他们分离了10种化合物:五种雅特罗类型的迪特尔类 (1-5),三种阿比类型的迪特尔类 (6-8) 和两种类 (9-10).
- 化合物1 (euphthymifolone A) 是一种新型化合物.
- 化合物9 (anabellamide) 和10 (aurantiamide) 是首次从Euphorbia属中分离出来的.
- 化合物1表现出氧化 (NO) 抑制活性,其IC50为65.4±1.36 μmol·L−1.1.
结论:
- 对Euphorbia thymifolia的化学研究产生了一种新型的二甲和几个已知的化合物.
- 隔离的新化合物通过NO抑制显示出潜在的抗炎性质.
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