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Updated: Jan 13, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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在多发性骨髓瘤中,PARP1的捕获激活了cGAS-STING通路,从而诱导免疫细胞死亡

Giada Juli1, Domenica Ronchetti2, Stefania Signorelli1

  • 1Department of Experimental and Clinical Medicine (DMSC), Magna Graecia University, Catanzaro, Italy.

Cancer cell international
|January 8, 2026
PubMed
概括

替代非同类末端结合 (Alt-NHEJ) 抑制剂显示出作为多发性髓瘤 (MM) 免疫刺激剂的前景. 使用塔拉佐巴里布准cGAS-STING通路会减少增殖,并诱导MM的免疫细胞死亡.

关键词:
造成的DNA损伤是DNA损伤.血液学的恶性瘤.在LIG3中,LIG3是指LIG3.多发性骨髓瘤是一种多发性骨髓瘤.PARP1 的第一部分cGAS-STING 的使用情况.

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