[从Aconitum吊的根源中制造出一种新的性糖化物]
Dan Dong1, Si-Qi Chen1, Nuan Jiang1
1College of Pharmacy, Qinghai Minzu University Xining 810007, China.
概括
从Aconitum摆形根中分离出了10种化合物,其中包括一种新型的性糖化物. 三种化合物 - - 甲基氨酸,14--8-O-甲基氨酸和 scopoletin - - 通过抑制巨细胞中氧化的产生来表现出抗炎作用.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- Aconitum pendulum是一种具有潜在药用特性的植物物种.
- 自然产品研究重点是从植物中分离生物活性化合物,用于治疗.
研究的目的:
- 为了隔离和识别来自Aconitum摆形根的化学成分.
- 评估分离化合物的抗炎活性.
主要方法:
- 使用二氧化染色学,凝染色学和半准备型HPLC的化合物隔离.
- 通过UV,IR,HR-ESI-MS和NMR光谱分析来阐明结构.
- 在体外抗炎测定使用LPS诱导的RAW264.7巨模型来测量氧化 (NO) 生产.
主要成果:
- 他们分离了10种化合物:两种化合物 (1-2),两种基 (3-4),五种二甲类化物 (5-9),以及一种素 (10).
- 化合物1是一种新基化物;化合物3,4,7,8和10首次从A. pendulum中报告.
- 甲基氨酸 (5),14--8-O-甲基氨酸 (6),和斯科波列丁 (10) 显著抑制了氧化的产生,其IC50值分别为34.1±1.3,28.0±1.0,20.3±1.7 μmol·L-1.
结论:
- 该研究成功地从Aconitum摆形根中分离和识别了十种化合物,包括一种新的性糖化物.
- 几种分离的化合物,特别是黄,14--8-O-甲基和 scopoletin,具有抗炎性质.
- 这些发现有助于了解Aconitum pendulum的植物化学特征和潜在的治疗应用.
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