阻塞性睡眠呼吸暂停和甲状腺激素敏感性之间的性别特异性关联在平衡性甲状腺成年人中
Beini Zhou1, Yixuan Wang1, Yuhan Wang1
1Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Street, 430060, Wuhan, China.
Biology of sex differences
|January 8, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 与甲状腺激素敏感性降低有关,但不影响甲状腺女性,但不影响男性. 这表明受影响女性潜在的亚临床下丘脑-垂体-甲状腺轴问题.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和甲状腺激素敏感性之间的相互作用尚未得到充分理解.
- 甲状腺激素敏感度指数可以提供超越标准激素水平评估的亚临床下丘脑-垂体-甲状腺 (HPT) 轴功能障碍的见解.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 严重程度与各种甲状腺激素敏感性指数之间的关联.
- 探索OSA和甲状腺激素敏感性之间的关系中的潜在的性别特异性.
主要方法:
- 对718名经过夜间睡眠监测的高甲状腺成年人进行分析.
- 使用TSHI,TFQI,PTFQI,TT4RI,TT3RI和FT3/FT4比率等指数评估中部和外围甲状腺激素敏感性.
- 包括ANCOVA和多变量线性回归在内的统计分析,使用性别分层模型并根据年龄和BMI进行调整.
主要成果:
- 在女性中,OSA与较高的FT4,增加的TFQI,PTFQI,TSHI,TT4RI以及较低的FT3/FT4比率有关,与非OSA个人相比.
- TFQI和TT4RI显示与女性OSA严重程度的增加有正相关性.
- 在女性中,OSA独立地与高TFQI,PTFQI,TSHI和TT4RI有关. 呼吸暂停-呼吸暂停指数 (AHI) 和氧气不和指数 (ODI) 与TT4RI相关. 在男性中没有发现任何显著的关联.
结论:
- 阻塞性睡眠呼吸暂停与中部和外围甲状腺激素敏感性受损有关.
- 这些发现并没有在甲状腺功能良好的男性中观察到,这表明性别特异性关系.
相关概念视频
Sleep Apnea
469
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
469
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
Major Hormones and Their Functions
1.7K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.7K
Other Pulmonary Disorders
1.5K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.5K
The Thyroid Gland
6.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.6K


