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DLGAP5驱动肺癌进展:结合生物信息学和临床预后分析

Min She^1,2, Chang Li², Fuxiang Li^1,3

¹Department of Respiratory Medicine and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou.

Journal of immunotherapy (Hagerstown, Md. : 1997)

|January 8, 2026

概括

增加DLGAP5表达与肺癌患者的整体存活率较低有关. 这一发现凸显了DLGAP5作为肺癌潜在的预后生物标志物和治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

DLGAP5是一种潜在的癌症生物标志物.
它在肺癌中的预后价值需要进一步研究.

研究的目的:

调查DLGAP5表达及其在肺癌的预后意义.
探索DLGAP5.5的潜在治疗向.

主要方法:

综合生物信息学分析与临床数据.
表达式分析和生存分析.
多变量考克斯回归和功能丰富分析.

主要成果:

DLGAP5表达在临床子组之间没有显著差异.
增加的DLGAP5与降低的整体存活率相关 (P=0.021).
DLGAP5是一个独立的风险因素,导致肺癌预后较差 (HR=2.35).

结论:

在肺癌中,DLGAP5具有显著的预后相关性.
DLGAP5可能成为肺癌治疗的潜在治疗标.

关键词:

在 DLGAP5 里面,你会看到 DLGAP5.生物信息学是一种生物信息学.肺癌是一种肺癌.预后预后预后生存分析,生存分析.

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