[来自Dendrobium nobile的两种新的双基衍生物及其抗瘤活性]
Pei-Wen DU1, Xiao-Yu Wei1, Bin Zhang1
1School of Food and Pharmacy, Zhejiang Ocean University Zhoushan 571158, China.
概括
研究人员从Dendrobium nobile叶子中分离了五种双基衍生物,其中两种新化合物显示出针对HeLa,MCF-7,A549和MGC-803癌细胞系的选择性抗瘤活性.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 药用化学 医学化学
背景情况:
- 丹德罗 (Dendrobium nobile) 是一种传统的药用草本.
- 从自然来源识别生物活性化合物对于药物发现至关重要.
研究的目的:
- 从Dendrobium nobile叶子中分离和识别具有抗瘤活性的化合物.
- 评估隔离化合物的体外抗瘤作用.
主要方法:
- 凝和凝柱色谱,中压准备色谱和HPLC用于隔离.
- 核磁共振 (NMR) 和高分辨率电喷射电离化质谱 (HR-ESI-MS) 用于结构阐明.
- 在实验室中对HeLa,MCF-7,A549和MGC-803细胞系进行了抗瘤活性评估.
主要成果:
- 分离并鉴定了五种双衍生物:克雷皮达 C (1), (S) -4,5,9-三基-2-甲基-9,10-二甲二烯 (2),克雷皮达 B (3),4,5-二基-2-甲基-9,10-二甲二烯 (4),和3',4,5'-三基-3-甲甲双 (5).
- 化合物1和2是新的,而化合物3-5是从D. nobile叶子中新分离出来的.
- 所有五种化合物都对测试的瘤细胞系表现出选择性抑制作用.
结论:
- 丹德罗 (Dendrobium nobile) 的叶子含有比基衍生物,在体外具有显著的抗瘤特性.
- 化合物1和2代表具有潜在治疗应用的新化学实体.
- 对这些化合物的进一步研究可能会导致新型抗癌剂的开发.
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