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[丁志药丸通过调节新陈代谢和神经可塑性来缓解小鼠LPS诱导的类似抑郁的行为]

Hao-Lin Chu¹, Nan Sun¹, Qin Tang²

¹School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|January 8, 2026

概括

丁志药,一种传统的中医药,通过减少炎症和调节关键的大脑信号通路,有效治疗抑郁症. 这项研究确定了与其抗抑郁作用有关的特定代谢物和途径.

科学领域:

药理学药理学是指药理学的学科.
神经科学是一个神经科学.
代谢学代谢学代谢学
传统中国医药传统中国医药

背景情况:

丁志药是一种用于治疗抑郁症的传统中医 (TCM) 配方.
丁志药在治疗抑郁症的确切作用机制尚不清楚.

研究的目的:

为了调查丁志药丸的抗抑郁疗效.
阐明其治疗作用中涉及的潜在代谢途径和分子机制.

主要方法:

化学成分使用超快速液体色谱学与四极飞行时间联质谱学 (UFLC-Q-TOF-MS/MS) 结合识别.
在行为绝望和脂聚糖 (LPS) 诱导抑郁症的小鼠模型中评估了抗抑郁药的效果.
对大脑组织进行的药理和代谢分析.

主要成果:

丁志药在小鼠中改善了类似抑郁症的行为,并减少了炎症性细胞因子 (TNF-α,IL-6).
它增强了BDNF,TrkB,mTOR和GluA1的表达,同时降低了谷氨酸水平.
代谢分析确定了46种独特的代谢物作为其抗抑郁作用的潜在生物标志物.

结论:

丁志药可以通过调节炎症反应和AMPA/BDNF/TrkB/mTOR信号通路来缓解抑郁症.
它影响了瓦林,氨酸,异氨酸和2氧碳酸盐代谢的生物合成.
提供科学证据支持Dingzhi Pills通过已识别的代谢途径对抗抑郁的作用.

关键词:

在AMPA/BDNF/TrkB/mTOR信号通路中.丁志药丸丁志药丸是一种药丸.抑郁抑郁症抑郁症抑郁症是一种谷氨酸酸盐的使用方法代谢生物组的代谢生物组

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