相关实验视频

Updated: Jan 13, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

[通过Epimedium多糖介导的自组装纳米颗粒来增强icariin的溶解和透]

Bin Huang¹, Yan-Jun Yang¹, Bing Yang¹

¹School of Traditional Chinese Pharmacy, Affiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University Nanjing 211198, China Jiangsu Provincial Key Laboratory of Pediatric Traditional Chinese Medicine and Specialized Formulations, Jumpcan Pharmaceutical Co., Ltd. Taixing 225400, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|January 9, 2026

概括

两个Epimedium多糖体,EPSN和EPSA,可以自组装成纳米粒子. 它们增强了icariin (ICA) 的溶解性,稳定性和透性,EPSA在溶解性/稳定性方面出色,EPSN在透性方面出色.

科学领域:

药理学和制药学药理学和制药学
生物材料科学生物材料科学
自然产品化学自然产品化学

背景情况:

来自传统中医药 (TCM) 聚糖的自组装纳米结构对药物输送有希望.
研究了Epimedium多糖体,特别是中性多糖体 (EPSN) 和酸性多糖体 (EPSA),以了解它们在药物输送系统中的潜力.

研究的目的:

探索EPSN和EPSA在纳米颗粒中的自我组装.
为了评估icariin (ICA) 对这些纳米结构的负载.
评估EPSN和EPSA对ICA生物制药性质的影响,包括溶解性,稳定性和透性.

主要方法:

结构特征 (例如,葡萄糖,异多聚糖,三环螺旋形状).
使用动态光散射 (DLS),临界聚合度 (CAC) 和电子显微镜进行纳米粒子形成分析.
使用里埃变换红外光谱 (FT-IR) 和差分扫描热量计 (DSC) 进行相互作用分析.
通过溶解性测试,胃肠稳定性测试,并行人工膜透性测试 (PAMPA) 和大鼠单通肠 perfusion (SPIP) 的生物制药性质评估.

主要成果:

在水溶液中自组装成纳米粒子的EPSN和EPSA.
在多糖和ICA之间观察到结合和π-π堆叠相互作用.
无论是EPSN还是EPSA,都显著提高了ICA的溶解性,稳定性和透性.
与EPSN相比,EPSA在溶解性和稳定性方面表现出优异的增强.
显示EPSN对改善ICA透性的效果更大.

结论:

EPSN和EPSA是有效的自组装材料,用于制造纳米粒子.
这些多糖类可以显著改善icariin (ICA) 的生物制药性质.
在EPSN和EPSA之间做出选择取决于所需的增强特征,EPSA倾向于溶解性/稳定性,EPSN倾向于透性.

关键词:

这是一种Epimedium多糖化物.功能组件是功能组件的组成部分.艾卡里尼因 (icariin) 是一种自组装的纳米粒子.

更多相关视频

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

相关概念视频

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...