检测不可检测的:用于新型精神活性物质的分析策略
Elisa Jousselin1, Pauline Griffeuille1,2, Isy Petit1
1Pharmacology and Transplantation, Inserm U1248, Université de Limoges, Limoges, France.
Therapeutic drug monitoring
|January 9, 2026
概括
检测新型精神活性物质 (NPS) 是一个挑战. 使用先进的质谱和人工智能 (AI) 的综合分析方法提高了毒理监测和公共卫生保护.
科学领域:
- 分析化学 分析化学
- 法医毒理学 法医毒理学
- 公共卫生监督 公共卫生监督
背景情况:
- 新型精神活性物质 (NPS) 由于结构多样性和低度而带来分析挑战.
- 认证参考材料的有限可用性阻碍了准确的检测.
- 本综述涉及NPS监控的分析策略和创新技术.
研究的目的:
- 审查目前和新兴的分析策略来检测NPS.
- 评估用于NPS毒理监测的创新技术.
- 强调先进技术在应对NPS挑战中的作用.
主要方法:
- 对染色学,光谱学,环境电离和人工智能辅助方法的系统审查.
- 强调在临床,法医和环境环境中适用性,敏感性和适应性.
- 分析传统和高分辨率技术,以及新兴的人工智能应用.
主要成果:
- 传统的方法仅限于已知的化合物;先进的技术提供更广泛的检测,但资源密集.
- 人工智能 (AI) 对非目标查和早期化合物识别有希望.
- 新兴的工具,如分子网络和基于废水的流行病学,可以增强实时监测.
结论:
- 结合高分辨率质谱,环境电离和人工智能的综合框架对于不断发展的NPS景观至关重要.
- 参考材料的标准化和跨学科的合作是提高NPS检测速度和灵敏度的关键.
- 加强分析能力对于保护公众健康免受新兴物质的侵害至关重要.
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