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相关概念视频

Urinary Bladder01:23

Urinary Bladder

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The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
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Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

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Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
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Disorders of the Urinary System01:20

Disorders of the Urinary System

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The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
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Physiology of Urine Formation01:24

Physiology of Urine Formation

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Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
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Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

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Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
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相关实验视频

Updated: Jan 13, 2026

A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
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尿蛋白质组变化 潜在的过度活跃的膀 与膀出口阻塞有关

Sang-Yeop Lee1,2, Ji Yong Lee3, Sung Ho Yun4

  • 1Biopharmaceutical Research Center, Korea Basic Science Institute, Cheongju, Korea.

International neurourology journal
|January 9, 2026
PubMed
概括

患有良性前列腺增生症 (BPH) 的男性的过度活性膀 (OAB) 显示了膀组织的分子变化,包括改变的细胞骨蛋白和免疫反应. 这些发现为治疗阻塞缓解后持续的OAB症状提供了新的目标.

关键词:
蛋白质组学是指蛋白质组学.膀部阻塞 尿道部阻塞膀,过度活跃的 尿道泌尿外皮是什么意思 泌尿外皮是什么意思

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相关实验视频

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科学领域:

  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 蛋白质组学是指蛋白质组学.
  • 分子生物学分子生物学

背景情况:

  • 由于良性前列腺增生 (BPH) 导致膀出口阻塞 (BOO) 的男性的过度活性膀 (OAB) 难以治疗.
  • 阻塞后缓解持续的OAB症状的分子机制尚不清楚.

研究的目的:

  • 在BOO相关的OAB患者的尿路组织中鉴定差异表达的蛋白质.
  • 使用蛋白质学方法来了解BPH患者的OAB病理生理学.

主要方法:

  • 从接受前列腺手术的BPH患者收集了膀泌尿器组织.
  • 将患者分为OAB和非OAB组.
  • 进行了液体染色学-双重质谱测量以进行蛋白质基因分析,随后进行了途径分析.

主要成果:

  • 确定了1510种蛋白质,其中133种在OAB组中表达不同.
  • 发现了失调的途径,包括细胞骨重塑,Rho GTPase信号传递和免疫反应.
  • 观察到结构蛋白的下调 (例如,ACTA2) 和炎症媒介和GNA13的上调.

结论:

  • 与BOO相关的OAB涉及细胞骨组织,神经递质通路和免疫反应的明显分子变化.
  • 这些蛋白质组发现为OAB病理生理学提供了洞察力.
  • 突出了生物标志物发现和治疗干预的潜在分子标.