Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

9.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.8K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

2.7K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.7K
Regulation of Food Intake01:30

Regulation of Food Intake

2.3K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.5K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

1.2K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.2K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

5.3K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Impaired mitochondrial flexibility hinders fat pad remodeling in obese mice after 24 h of fasting.

Life sciences·2026
Same author

Epicardial Fat Drives Macrophage Response in Atrial Cardiomyopathy.

Circulation research·2026
Same author

Nationwide decline in psychiatric hospitalizations and costs in Brazil, 2008-2022: a retrospective descriptive study evidencing reform-driven community mental health gains.

Lancet regional health. Americas·2026
Same author

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.

Nature communications·2026
Same author

How Adipocytes Orchestrate Inflammation Within Adipose Tissue?

Biomolecules·2026
Same author

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1<sup>+</sup> cDC1 infiltration and activates anti-tumor immunity.

Nature communications·2025

相关实验视频

Updated: Jan 13, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.7K

TNF/TNFR1是长期禁食诱导脂肪组织下降的关键调节者.

Amanda Carla Clemente de Oliveira1,2,3, Adma Maciel Babêtto1,2, Mariele Lino Silva1,2

  • 1Immunometabolism, Department of Nutrition, Nursing School, Federal University of Minas Gerais, Belo Horizonte, Brazil.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|January 9, 2026
PubMed
概括

瘤坏死因子 (TNF) 和它的受体TNFR1对于禁食期间的脂肪减轻至关重要. 阻断TNF可以防止脂肪减少,突出显示TNF/TNFR1通路.

关键词:
介质蛋白-18 介质蛋白-18 介质蛋白脂肪组织的脂肪组织.减肥手术 减肥手术是什么长时间的禁食.瘤死亡因子是瘤死亡因子.

更多相关视频

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.8K
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

3.6K

相关实验视频

Last Updated: Jan 13, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.7K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.8K
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

3.6K

科学领域:

  • 代谢适应 代谢适应
  • 脂肪组织生物学 脂肪组织生物学
  • 炎症和免疫的作用

背景情况:

  • 营养素的可用性会影响白色脂肪组织 (WAT) 的炎症和脂肪性.
  • 在不同的营养条件下,瘤亡因子 (TNF) 在WAT中升高.
  • 在低能量可用性期间,TNF和IL-18在减肥中的作用尚不清楚.

研究的目的:

  • 研究TNF/TNFR1信号传递在禁食诱导脂肪减轻中的作用.
  • 为了确定IL-18在禁食期间脂肪损失中的参与.
  • 评估这些发现在人类肥胖症中的翻译相关性.

主要方法:

  • 使用了野生型 (WT),TNFR1淘汰和IL-18淘汰的小鼠.
  • 使用禁食协议 (24h和48h) 和β3-上腺素受体激动剂 (CL316,243).
  • 分析了来自53名肥胖患者的皮下WAT (sWAT) 样本.

主要成果:

  • TNFR1淘汰赛小鼠在禁食和激动剂治疗后抵抗脂肪损失.
  • 通过infliximab抑制TNF也导致了对禁食诱导的脂肪损失的抵抗.
  • 在禁食期间,IL-18淘汰赛小鼠的反应与WT小鼠的反应类似,这表明IL-18对脂肪损失不至关重要.
  • 在人类sWAT中,TNFR1和IL-18的表达与脂质酶和脂蛋白相关,但与体重无关.

结论:

  • 在雄性小鼠中,TNF/TNFR1轴对代谢适应和禁食诱导的脂解至关重要.
  • 长时间的禁食诱导的TNF信号传递是脂肪组织减少的先决条件.
  • TNF/TNFR1通路可能在人类肥胖中具有翻译相关性,特别是关于代谢适应.