鉴定注意力缺陷/过度活动障碍与冠状动脉疾病和心力衰竭之间的调解途径:两步多变量孟德尔随机化研究
Jing Lin1,2, Yiling Zhou1, Tian Xie1,3
1Department of Epidemiology, University of Groningen, https://ror.org/03cv38k47University Medical Center Groningen, Groningen, The Netherlands.
注意缺陷/多动障碍 (ADHD) 因果上增加了冠状动脉疾病和心力衰竭的风险. 诸如教育程度和吸烟等可修改因素调解了这些心血管疾病风险,这表明了干预目标.
科学领域:
- 心血管流行病学心血管流行病学
- 精神病学遗传学 精神病学遗传学
- 门德尔的随机化 门德尔的随机化
背景情况:
- 注意缺陷/多动障碍 (ADHD) 与心血管疾病 (CVD) 风险增加有关.
- 这种关联的因果性和介导途径尚不清楚.
研究的目的:
- 研究ADHD与冠状动脉疾病 (CAD) 和心力衰竭 (HF) 之间的因果关系.
- 量化可修改风险因素在ADHD-CVD关系中的调解作用.
主要方法:
- 一个两步,两样本的门德尔随机化研究设计.
- 利用了ADHD,调解剂,CAD和HF全基因组关联研究的总结统计数据.
- 使用遗传变异 (SNP) 作为工具变量.
主要成果:
- 基因预测的ADHD显示CAD (OR 1.13) 和HF (OR 1.11) 的几率增加.
- 教育成就显著调解了ADHD-CAD联系 (32.27%);BMI,T2D,EA,吸烟开始和抑郁症解释了83.59%的关联.
- 吸烟开始显着调解了ADHD-HF联系 (35.87%);BMI,T2D和SI解释了82.39%的关联.
结论:
- 证据支持ADHD与CAD和HF风险增加之间存在因果关系.
- 可修改的因素在很大程度上调解了这些关联,突出了在ADHD人群中降低心血管疾病风险的潜在干预目标.
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