PDMD:关于骨肌相关疾病报告的植物综合存储库
1Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India.
Current drug targets
|January 9, 2026
概括
一个新的数据库,PDMD,列出了用于肌肉消耗疾病的药用植物,如肉症和缓解症. 这种资源是民族药理学和植物学的桥梁,有助于发现新的基于植物的肌肉健康疗法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 植物学 植物学
- 生物信息学是一种生物信息学.
背景情况:
- 关于植物疾病关联的数据库往往缺乏关于骨肌肉消耗的信息.
- 现有的文献表明,植物提取物和化合物可以在模型生物体中有益于肌肉消耗条件.
- 需要一个全面的资源来记录用于肌肉消耗疾病的药用植物.
研究的目的:
- 介绍关于肌肉消耗疾病 (PDMD) 的植物数据库.
- 提供与肌肉衰竭相关的植物及其化合物的手工策划的存储库.
- 促进对植物性治疗方法的研究,以治疗卡赫克西亚,肉症和肌肉缩等疾病.
主要方法:
- 从PubMed,Science Direct和其他来源系统地手动整理研究.
- 使用ClassyFire和PubChem等工具提取植物化学和分类学数据.
- 使用MS-Excel和MySQL开发数据库,在Visual Studio Code和HTML/CSS中提供前端,并通过Apache/PHP服务器集成.
主要成果:
- PDMD含有206种药用植物和230种活性药物成分 (API).
- 信息包括分类学,植物化学类,SMILES结构,地理分布和生物活性.
- 该数据库与PubChem和PubMed进行交叉引用,以增强功能.
结论:
- PDMD强调了植物和肌肉健康之间的低估的联系.
- 该数据库弥合了民族药理学和植物学方面的差距.
- PDMD可以帮助产生新的肌肉消耗疗法的假设.
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