在激素替代治疗后保留受孕产品的发生率与冷胚胎移植中的自然周期相比
Akiko Shimada1, Yoshikazu Kitahara2, Mitsuo Obara1
1HILLS Ladies Clinic Maebashi Japan.
Reproductive medicine and biology
|January 9, 2026
概括
在使用激素替代周期 (HRC) 的冷解胚胎移植怀孕中,与自然周期 (NC) 相比,保留的受孕产物 (RPOC) 更常见. 需要进一步的研究来证实这些发现.
科学领域:
- 生殖医学 生殖医学
- 产科和妇科 产科和妇科
- 胚胎转移技术的使用
背景情况:
- 留存的受孕产物 (RPOC) 是怀孕后的潜在并发症.
- 冷解胚胎移植 (FET) 涉及不同的制备方案,包括激素替代周期 (HRC) 和自然周期 (NC).
- 了解影响辅助生殖技术中RPOC发生率的因素对于患者安全至关重要.
研究的目的:
- 调查冷解胚胎移植 (FET) 怀孕中保留的受孕产物 (RPOC) 的发生率.
- 为了比较激素替代周期 (HRC) 和自然排卵周期 (NC) 之间的RPOC率.
主要方法:
- 在FET之后,对425例临床怀孕进行了回顾性分析.
- 怀孕的分类为HRC (n=204) 或NC (n=221) 组.
- 通过超声波,多普勒和组织病理学诊断RPOC;使用精确测试和Firth惩罚后勤回归的统计分析.
主要成果:
- RPOC发生在3.3%的怀孕中 (14/425).
- 与NC (1.4%) 相比,HRC (5.4%) 的发生率明显高.
- 在HRC与NC中RPOC的调整后几率比为3.92 (95%CI1.18-12.96).
结论:
- 激素替代周期 (HRC) 与FET怀孕中保留受孕产物 (RPOC) 的更高发病率有关.
- 这些发现表明,胎盘分离可能存在与协议相关的差异.
- 需要进行更大规模的前性多中心研究来验证这些探索性结果.
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