根据性别,年龄,体重,身高或手臂跨度调整的成年人对螺旋测量,体缩和扩散能力的参考值 - 丹麦肺功能研究材料 (DALFUMAT)
Jann Mortensen1,2,3,4, Lars Kristensen5,6, Mathias Munkholm1
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital- Rigshospitalet, Copenhagen, Denmark.
开发了新的丹麦肺功能参考值 (DALFUMAT),发现与现有的GLI和ECCS值有很大差异. 建议在全国范围内采用这些更新的肺体积和扩散能力参考值.
科学领域:
- 肺部生理学 肺部生理学
- 呼吸系统医学 呼吸系统医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 现有的肺功能参考值可能不准确地反映当前人口.
- 全球肺功能倡议 (GLI) 和欧洲煤炭和钢铁共同体 (ECCS) 提供了广泛使用的参考方程.
- 准确的参考值对于诊断和管理呼吸道疾病至关重要.
研究的目的:
- 为丹麦的动态和静态肺体积和一氧化碳扩散能力建立新的国家参考值.
- 将这些新值与现有的GLI和ECCS参考值进行比较.
- 根据手臂跨度和支气管扩展器后的螺旋计,开发肺功能的参考值.
主要方法:
- 908名健康的非吸烟者 (年龄在18-97岁之间) 接受了螺旋测量,身体囊造影和单呼吸扩散能力测试.
- 使用了多重回归分析,包括性别,年龄,体重和身高 (或手臂跨度).
- 质量控制遵循ATS/ERS标准,与GLI和ECCS预测值进行比较.
主要成果:
- 为29个肺功能参数建立了性别特定的参考方程.
- 新的参考值与GLI和ECCS在临床上有显著差异,特别是在女性和流量/体积参数中.
- 还确定了支气管扩展剂反应参考值,包括z分数.
结论:
- 新开发的丹麦肺功能参考值 (DALFUMAT) 与当前的国际标准 (GLI,ECCS) 有显著差异.
- 这些差异需要重新评估丹麦人口的诊断值.
- 建议在全国范围内采用DALFUMAT参考值,以提高肺功能评估的准确性.
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