黄类药物摄入量与动脉硬之间的关联:PERSIAN队列研究
Sara Ghodrat1, Mostafa Shahraki Jazinaki1, Reza Rezvani1
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna journal of phytomedicine
|January 9, 2026
概括
在成年人中,高摄入的黄类药物并没有显著降低动脉硬或血压. 需要进一步的研究来证实黄类药物对心血管疾病风险因素的影响.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 是一个主要的全球健康问题,需要有效的预防策略.
- 饮食因素,如黄酸盐摄入量,正在研究它们在预防心血管疾病中的潜在作用.
- 动脉硬是心血管事件的关键预测因素.
研究的目的:
- 为了研究总体黄类摄入量和个人黄类子类摄入量与动脉硬性之间的关联.
- 为了检查黄类药物摄入量与血压水平之间的关系.
- 评估黄素在预测心血管疾病风险方面的作用.
主要方法:
- 使用PERSIAN队列研究 (n=3423,年龄在35-70岁之间) 的数据进行横截面研究.
- 使用食物频率问卷和Phenol Explorer数据库评估的黄类素摄入量.
- 测量了动脉硬度 (脉冲波速度,中央增强指数) 和血压.
- 统计分析包括单变量和多变量后勤回归来调整混因素.
主要成果:
- 总的黄类药物摄入量与脉冲波速度 (PWV) 和中央增强指数 (AIx) 的高风险水平有非显著的反向关联.
- 没有发现任何黄类子类的摄入量与高风险的动脉硬或血压之间存在显著的关联.
- 总黄摄入量最高五分位数与最低五分位数的几率比率为PWV的0.83 (95% CI:0.65-1.06) 和AIx的0.95 (95% CI:0.74-1.21).
结论:
- 这项研究发现,总的黄类摄入量或特定的黄类子类与动脉硬或血压之间没有显著的关联.
- 目前的证据不支持黄类药物在这种群体中对动脉硬的保护作用.
- 需要进一步的研究,以确定黄类药物对动脉硬性和心血管疾病预防的影响.
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