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Updated: Jan 13, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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保护性IFIH1变体减少了1型糖尿病遗传背景的免疫媒介小岛压力和功能障碍

Daniel A Veronese-Paniagua1,2, Cameron Banks2, Kameron Bradley2,3

  • 1Roy and Diana Vagelos Division of Biology and Biomedical Sciences Washington University School of Medicine, St. Louis, MO 63112, USA.

bioRxiv : the preprint server for biology
|January 9, 2026
PubMed
概括

一种特定的MDA5基因变异 (E627*) 保护胰腺小岛细胞免受1型糖尿病 (T1D) 的触发. 这种MDA5变体减少了T1D干细胞模型中的免疫反应,细胞死亡和功能障碍.

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