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Updated: May 7, 2026

Mouse Models of Periventricular Leukomalacia
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Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

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在小鼠中MBP3' UTR的缺失破坏了mRNA运输,髓化和运动学习

Joseph C Nowacki, Haidyn L Bulen, Lindsey M Meservey

    bioRxiv : the preprint server for biology
    |January 9, 2026
    PubMed
    概括

    髓基本蛋白 (MBP) 的mRNA局部化对于髓膜发育至关重要. 我们的研究表明,MBP mRNA沿着actin纤维线传播,而不是微管,影响髓化和运动功能.

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    相关概念视频

    Nonsense-mediated mRNA Decay02:27

    Nonsense-mediated mRNA Decay

    The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
    Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...