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Updated: Jan 13, 2026

Isolation and In vitro Culture of Bone Marrow-Derived Macrophages for the Study of NO-Redox Biology
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Published on: May 31, 2022

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多原子分析揭示了古典激活巨细胞中依赖氧化的重塑,并确定了由AKR1A1介导的负调节

Nicholas L Arp, Uzziah S Urquiza, Marcel Morgenstern

    bioRxiv : the preprint server for biology
    |January 9, 2026
    PubMed
    概括

    氧化 (NO•) 通过重塑电子运输链并调节像AKR1A1.1.这样的氧化还原防御酶来广泛调节巨细胞激活. 这种依赖NO的AKR1A1诱导微调免疫反应和代谢转变.

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