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相关概念视频

Spermatogenesis01:41

Spermatogenesis

121.6K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.6K
Fertilization01:38

Fertilization

89.6K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.6K

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相关实验视频

Updated: Jan 13, 2026

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
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Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation

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在体外培养过程中对小鼠精子子子群的组合分析.

Benjamin M Brisard, Aishwarya P Halder, Aidan Charles

    bioRxiv : the preprint server for biology
    |January 9, 2026
    PubMed
    概括

    精子容量表现出显著的异质性. 新的方法揭示了碳酸盐和如何控制精子子群,将它们的结构与生育潜力联系起来,并改进了用于男性生育能力评估的流细胞计分析.

    科学领域:

    • 生殖生物学 生殖生物学
    • 细胞生理学 细胞生理学
    • 生物统计学 生物统计学

    背景情况:

    • 哺乳动物的精子需要电容来受精卵,这个过程表现出相当大的细胞对细胞的变异性.
    • 了解容量化期间的精子亚种群动态对于评估男性生育能力至关重要,但目前的方法往往会独立分析细胞.
    • 环境信号和精子表型异质性之间的相互作用仍然不太清楚.

    研究的目的:

    • 在体外测量精子种群结构对受控电容信号的响应.
    • 研究二碳酸盐和在调节精子子群中的非线性相互作用.
    • 开发一个统计框架来分析精子亚种群动态,并将其与生育能力联系起来.

    主要方法:

    • 在小鼠精子上利用大规模单细胞光谱流细胞计.
    • 实施了二维测试,改变了细胞外二碳酸盐和自由水平.
    • 应用了层次的迪里克莱特多项式回归模型来进行亚群级别的分析,并考虑变异性.

    主要成果:

    • 二碳酸盐和非线性相互作用,将精子重新分配到不同的生理状态 (活力,体反应状态).
    • 细胞内的升高与精子死亡的增加相关,而在细胞外低的情况下观察到最佳的活体,体反应的精子种群.
    • 开发的统计模型提供了概率表面,显示子群体在响应微环境变化时的变化.

    更多相关视频

    Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
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    Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

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    Author Spotlight: A Live Cell Imaging Technique to Study Calcium Signaling and Acrosome Exocytosis in Mouse Sperm
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    Author Spotlight: A Live Cell Imaging Technique to Study Calcium Signaling and Acrosome Exocytosis in Mouse Sperm

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    相关实验视频

    Last Updated: Jan 13, 2026

    Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
    08:22

    Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation

    Published on: January 22, 2020

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    Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
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    Phosphopeptide Analysis of Rodent Epididymal Spermatozoa

    Published on: December 30, 2014

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    Author Spotlight: A Live Cell Imaging Technique to Study Calcium Signaling and Acrosome Exocytosis in Mouse Sperm
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    Author Spotlight: A Live Cell Imaging Technique to Study Calcium Signaling and Acrosome Exocytosis in Mouse Sperm

    Published on: October 13, 2023

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    结论:

    • 精子电容是一种随机过程,其特点在于在人口层面上具有结构化的表型异质性.
    • 这项研究提供了一个定量框架,将精子亚种群组成与生育能力联系起来.
    • 这些发现为男性生育能力评估提供了流细胞计数据的改进解释.