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Updated: Jan 13, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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不同的 lysosomal 功能障碍 PROGRANULIN 在 CNS 缺陷的模式 暗示 PROGRANULIN 在细胞类型特定的蛋白质分类

Gordon C Werthmann, Joachim Herz

    bioRxiv : the preprint server for biology
    |January 9, 2026
    PubMed
    概括

    进展素 (GRN) 缺乏会破坏大脑细胞中的溶酶体组成,影响脂质代谢和溶酶体组织. 这突出了GRN在蛋白质分类中的作用,并指导了相关神经退行性疾病的治疗策略.

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