慢性伤口愈合中的非编码RNA:机制,外体治疗和转化边界
Lingjing Yang1,2, Yehui Lv1,2
1Institute of Wound Prevention and Treatment, Shanghai University of Medicine & Health Sciences, China.
Journal of tissue engineering
|January 9, 2026
概括
通过外体传递的非编码RNA (ncRNA) 显示出通过调节炎症和组织修复来治疗慢性伤口的前景. 先进的药物输送系统,包括水凝和AI,提高了ncRNA治疗的有效性.
科学领域:
- 生物医学工程 生物医学工程
- 分子生物学分子生物学
- 再生医学是一种再生医学.
背景情况:
- 慢性伤口存在严重的临床挑战,原因是炎症,血管形成不良,以及异常的组织修复.
- 非编码RNAs (ncRNAs),如microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),是这些伤口愈合过程的关键调节者.
- 竞争性内源性RNA (ceRNA) 网络,涉及ncRNAs,在病理条件下精确控制基因表达.
研究的目的:
- 审查ncRNAs在慢性伤口治疗中的治疗潜力.
- 探索ncRNAs的先进传递系统,包括外体和水凝.
- 讨论机器学习 (ML) 和人工智能 (AI) 在开发个性化慢性伤口治疗中的整合.
主要方法:
- 外体被用来通过基因编辑或化学修饰有效地和有针对性地传递ncRNA.
- 像水凝这样的生物材料与外体相结合,以确保持续的ncRNA释放和长时间的治疗效果.
- 机器学习 (ML) 和人工智能 (AI) 正在研究预测患者特定的ceRNA网络和设计智能伤口包裹.
主要成果:
- 基于外体的输送系统在临床前慢性伤口模型中表现出高效率和准能力.
- 水凝复合物增强了外体稳定性,并使持续的ncRNA释放成为可能,改善了治疗结果.
- 人工智能和机器学习通过预测ceRNA相互作用和根据个体患者需求量身定制治疗,为个性化医疗提供了潜力.
结论:
- 基于ncRNA的疗法,通过外体传递,并通过生物材料和人工智能增强,代表了慢性伤口管理的前沿.
- 将先进的药物输送系统与个性化医疗方法相结合,可以显著提高复杂伤口的治疗效率.
- 本次审查强调了将基础研究与针对性慢性伤口治疗的临床应用联系起来的潜力.
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