识别长期COVID的亚型:系统性审查
Bingyi Wang1,2,3,4,5,6, Xufei Luo1,2,3,4,5, Meihua Wu7
1Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China.
本综述总结了长期COVID分类方法,发现症状并发和器官系统参与是关键. 疲劳和嗅觉-口味功能障碍是长期COVID亚型中常见的核心症状.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID呈现出SARS-CoV-2感染后的多样化,持久的症状.
- 有效的管理需要了解和分类患者亚型.
研究的目的:
- 系统地审查和总结现有的方法,以集群和分类长期COVID患者和症状.
- 支持改善长期COVID的临床管理策略.
主要方法:
- 按照PRISMA指南进行系统的文献搜索 (PubMed,Embase,科学网,谷歌学者).
- 数据提取和合格研究的质量评估.
- 对症状共发生网络的分析和基于器官系统的症状集群的元分析.
主要成果:
- 包括64项研究 (47个队列,17个横截面),共有243万参与者.
- 确定了四种主要的分类方法:症状同时出现 (46.9%),器官系统 (25.0%),严重程度 (14.1%) 和临床指标 (4.7%).
- 疲劳,嗅觉胃口功能障碍,焦虑抑郁和关节/肌肉疼痛是常见的症状集群/染色体. 呼吸系统 (47%),神经系统 (31%) 和胃肠道 (28%) 的症状群是最常见的.
结论:
- 症状并发和器官系统参与是长期COVID分类的主要方法.
- 疲劳和嗅觉-口味功能障碍是长期COVID亚型中经常出现的核心症状.
- 了解这些分类有助于有针对性的长期COVID管理和研究.
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